Reviewing concepts in the immunopathogenesis of psoriasis.
نویسندگان
چکیده
Insights into the pathogenesis of psoriasis led to the development of therapeutic tools aimed at blocking its immunological trigger. In parallel, cytokines such as the tumor necrosis factor (TNF) have been recognized as playing a crucial role in the pathogenesis of psoriasis and its associated comorbidities. Genetic and immunological studies have contributed effectively towards establishing the currently held concepts regarding this complex disease.
منابع مشابه
Better Understanding the Immunopathogenesis of Pso- riasis
The immunopathogenesis of psoriasis involves complex interactions between the innate and the adaptive immune system, with emphasis on participation of keratinocytes, neutrophils, dermal dendritic cells and T lymphocytes.The knowledge of the immunopathogenesis of the disease is essential for understanding the mechanism of action of several systemic medications used in the treatment of the diseas...
متن کاملبررسی ارتباط بین سطوح سرمی سیتوکین‌های ترشح شده از سلول‌های Th1،Th2، اینترلوکین 8 و ICAM-1 با شدت بیماری پسوریازیس براساس PASI
Background & Aim: Psoriasis is a common chronic inflammatory skin disease that affects 1-3% of the world's population. It can cause significant distress to the patient and ultimately the reduction of the patient's life quality. From the clinical perspective, it can create bright, red, elevated, and scaly plaques. Psoriasis is now recognized as a T-cell mediated disease with epidermal hyperp...
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Current knowledge of the immunopathogenesis of psoriasis vulgaris is based on the crucial role of CD4 and CD8 lymphocytes. Also, the connection of activated lymphocytes with macrophages, especially dendritic cells and plasmacytoid dendritic cells, is considered to be significant. In the present study, the expression of CD4+ lymphocytes as well as CD8+ lymphocytes (P < 0.001) and macrophages (P ...
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Psoriasis is a common inflammatory disease affecting 1% of the Brazilian population. Th17 and Th1cells are involved with the immunopathogenisis of psoriasis. In this article it is discussed the interaction between the innate immunity (especially dendritic cells and keratinocytes) and adaptive immunity (T lymphocytes) in the pathogenesis of psoriasis.
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عنوان ژورنال:
- Anais brasileiros de dermatologia
دوره 86 6 شماره
صفحات -
تاریخ انتشار 2011