Reviewing concepts in the immunopathogenesis of psoriasis.

نویسندگان

  • Emerson de Andrade Lima
  • Mariana de Andrade Lima
چکیده

Insights into the pathogenesis of psoriasis led to the development of therapeutic tools aimed at blocking its immunological trigger. In parallel, cytokines such as the tumor necrosis factor (TNF) have been recognized as playing a crucial role in the pathogenesis of psoriasis and its associated comorbidities. Genetic and immunological studies have contributed effectively towards establishing the currently held concepts regarding this complex disease.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Better Understanding the Immunopathogenesis of Pso- riasis

The immunopathogenesis of psoriasis involves complex interactions between the innate and the adaptive immune system, with emphasis on participation of keratinocytes, neutrophils, dermal dendritic cells and T lymphocytes.The knowledge of the immunopathogenesis of the disease is essential for understanding the mechanism of action of several systemic medications used in the treatment of the diseas...

متن کامل

بررسی ارتباط بین سطوح سرمی سیتوکین‌های ترشح شده از سلول‌های Th1،Th2، اینترلوکین 8 و ICAM-1 با شدت بیماری پسوریازیس براساس PASI

    Background & Aim: Psoriasis is a common chronic inflammatory skin disease that affects 1-3% of the world's population. It can cause significant distress to the patient and ultimately the reduction of the patient's life quality. From the clinical perspective, it can create bright, red, elevated, and scaly plaques. Psoriasis is now recognized as a T-cell mediated disease with epidermal hyperp...

متن کامل

The role of CD4 and CD8 lymphocytes and macrophages in psoriasis vulgaris.

Current knowledge of the immunopathogenesis of psoriasis vulgaris is based on the crucial role of CD4 and CD8 lymphocytes. Also, the connection of activated lymphocytes with macrophages, especially dendritic cells and plasmacytoid dendritic cells, is considered to be significant. In the present study, the expression of CD4+ lymphocytes as well as CD8+ lymphocytes (P < 0.001) and macrophages (P ...

متن کامل

Progress in understanding the immunopathogenesis of psoriasis.

This review emphasizes how translation from bench research to clinical knowledge and vice versa has resulted in considerable progress in understanding the immunopathogenesis of psoriasis. First, the journey in understanding the pathogenic mechanisms behind psoriasis is described. The roles of different components of the adaptive and innate immune systems involved in driving the inflammatory res...

متن کامل

Immunopathogenesis of psoriasis.

Psoriasis is a common inflammatory disease affecting 1% of the Brazilian population. Th17 and Th1cells are involved with the immunopathogenisis of psoriasis. In this article it is discussed the interaction between the innate immunity (especially dendritic cells and keratinocytes) and adaptive immunity (T lymphocytes) in the pathogenesis of psoriasis.

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Anais brasileiros de dermatologia

دوره 86 6  شماره 

صفحات  -

تاریخ انتشار 2011